Search for: All records

The majority of physics and astronomy undergraduate major classes are structured around problem sets, an approach that does not typically make it possible for students to learn in an inquiry-based manner analogous to how scientists conduct research. One of the reasons professors often do not attempt an inquiry approach is the lack of educational tools needed to facilitate this method of learning. In this work, I describe how Astrobites — a website run by astronomy graduate students with the goal of making the latest research more accessible to undergraduates — is ideally suited to serve as an educational tool that can make problem sets more inquiry-based. I discuss how I designed inquiry-based problem sets that make use of Astrobites for several different astronomy classes that target physics and astronomy majors. I also present strategies for implementing such assignments based on assessment from the students, and provide example problem sets that received good student feedback. These assignments are intended to complement traditional problem sets, thereby inclusively providing an alternate way for students to take interest and engage in their homework for the class. 

Abstract ObjectiveTo characterize a cohort of patients withSCN8A‐related epilepsy and to perform analyses to identify correlations involving the acquisition of neurodevelopmental skills. MethodsWe analyzed patient data (n = 91) submitted to an online registry tailored to characteristics of children withSCN8Avariants. Participants provided information on the history of their child's seizures, medications, comorbidities, and developmental skills based on the DenverIIitems. Spearman rank tests were utilized to test for correlations among a variety of aspects of seizures, medications, and neurodevelopmental progression. ResultsThe 91 participants carried 71 missense variants (41 newly reported) and three truncating variants. Ages at seizure onset ranged from birth to >12 months of age (mean ± SD = 5 months 21 days ± 7 months 14 days). Multiple seizure types with multimodal onset times and developmental delay were observed as general features of this cohort. We found a positive correlation between a developmental score based upon percentage of acquired skills and the age at seizure onset, current seizure freedom, and initial febrile seizures. Analyses of cohort subgroups revealed clear distinctions between patients who had a single reported variant inSCN8Aand those with an additional variant reported in a gene other thanSCN8A, as well as between patients with different patterns of regression before and at seizure onset. SignificanceThis is the first study of anSCN8A patient cohort of this size and for which correlations between age at seizure onset and neurodevelopment were investigated. Our correlation studies suggest that variants of uncertain significance should be considered in assessing children withSCN8A‐related disorders. This study substantially improves the characterization of this patient population and our understanding of the neurodevelopmental effects associated with seizures forSCN8A patients, and provides a clinical context at initial presentation that may be prognostic for developmental outcome.